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Thorne

Methyl-Guard Plus®, 90 Capsules

4.9 · 2873 reviews
6,584 ₽

Methylation Factors Dietary Supplement Heart / Vessels Mood Gluten Free Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation. Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.

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Methylation Factors Dietary Supplement Heart / Vessels Mood Gluten Free Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation. Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.

Customer reviews

5.0
verified purchase
Love this product

I finally realised after many years of chronic health problems and now Lyme disease that I have a problem with the methylation of folate therefore causing toxins to build up in my body and leaving a high folate residue of folate that can't be metabolised. This is a great product containing the methylated form of folate

7/5/2018
5.0
verified purchase
A staple since finding out I have MTHFR

Since I found out I have the MTHFR mutation, methylated B vitamins have genuinely changed things for me. More energy, less brain fog, steadier mood. Thorne's Methyl-Guard Plus uses the active forms of folate, B12 and B6 (methylfolate, methylcobalamin, P5P) so your body doesn't have to convert them first, which matters a lot if you have MTHFR like I do. Thorne is also one of the brands I trust most for quality, clean formula, gluten free, nothing unnecessary added. I take it every day and I recommend it to a lot of my coaching clients too. It's become one of those products I actually trust.

8/22/2026
5.0
verified purchase
Amazing

Love this brand. Perfect methylated vitamins and good ingredients. The quality is great and these are the perfect supplement to add to your list of you have the MTHFR gene and have a problem with methylating.

1/28/2026
5.0
verified purchase
thank you

Comprehensive methylation support formula with bioactive B‑vitamins (including methylated folate and B12 forms) plus cofactors that help support cellular energy, nervous system function, and homocysteine metabolism. Clean, minimal‑filler profile and easy‑to‑take capsules make daily use simple. Practical choice if you want advanced B‑vitamin support for methylation pathways as part of a broader wellness routine.

1/11/2026
5.0
verified purchase
RX Quality

Thorne is a high quality RX level supplement company I used Methyl Guard as prescribed by my ND due to an MTHFR issue It has very high levels of B12 along with B6, Folate and TMG There is also Methyl Guard Plus I switch between this product and Thorne B Vitamin Complex You can not beat the quality of Thorne

11/28/2025
5.0
verified purchase
Clean

My GP recommended I go to the effort of buying this online rather than grabbing something off the shelves in an Australian Chemist. Thorne is a quality product.

11/23/2025
5.0
verified purchase
targeted for homocisteine

clean and therapeutic dosage, capsules are easy to swallow, no off smell. The lab test is gonna see if it was effective after 3 months

11/13/2025
5.0
verified purchase
Love it

Easy to swallow. I have MS and I don’t really feel it, but I know this helps together with the other things I take. I love iHerb, you can find everything you need there.

11/4/2025
5.0
verified purchase
Great for MTFHR

This is a great vitamin supp for those with the MTFHR gene as it has methlyated B's that can be absorbed by our systems. Very helpful!

10/23/2025
5.0
verified purchase
Mental Clarity for Play Calls

Thorne Methyl-Guard Plus has helped me find extra focus and better mood, which meant smoother decisions under Friday night lights and less stress managing tight schedules. The potency, and how much days have help. Once again comes down to the quality and the effectiveness of the their ingredients compared to others, but I have taken.

10/21/2025